Profhilo Structura: The Definitive 2026 Guide to Mid-Face Bio-Remodelling

For the past few years, Profhilo has been the quietly clever answer to dull, lax skin. It rewrote how we think about skin quality. But there has always been a question hovering just behind it: what about the foundation underneath?

Profhilo Structura is the answer. It is the first injectable specifically engineered to bio-remodel the superficial fat pads of the mid-face - the structural cushions that quietly deflate from your mid-thirties onwards. It does not add volume in the way a filler does, nor does it freeze movement. Profhilo Structura benefits you by teaching the tissues you already have how to behave more youthfully.

At The Skin to Love Clinic in St Albans, we are among the first medically led, CQC-registered clinics in Hertfordshire to offer it. This is the definitive 2026 guide with commentary, as ever, by the medical team who treat with it

Beyond the glow: why Profhilo Structura is different

Standard Profhilo works in the dermis. Profhilo Structura, on the other hand, works in the adipose layer which is the superficial fat pads sitting between skin and bone, which give the mid-face its youthful projection and contours.

It is a stabilised hyaluronic acid at a concentration of 90mg per 2ml syringe, manufactured using IBSA's NAHYCO Hybrid Technology. That is 40.6% more concentrated than original Profhilo, and the molecule is engineered to behave differently in the tissues.

It’s important to highlight that not only do we not treat it like a filler in practice, chemically it is not the same as a dermal filler; it is not cross-linked and is BDDE-free, so it is categorically not a filler.

Once placed, three things happen simultaneously:

• Support of the adipocyte environment: promoting better cell positioning and tissue cohesion without artificially expanding the area.
• Stimulation of fibroblast and keratinocyte activity: encouraging your skin to produce new collagen, elastin and hyaluronic acid of its own.
• Remodelling of the surrounding ligament and fascial support: which is the structural element that gives the gentle, natural-looking lift.

The clinical term for this combined action is fat pad remodelling, and Profhilo Structura is the first injectable to be indicated specifically for it.

Sinkers vs Saggers: which pattern of mid-face ageing do you have?

Mid-face ageing typically follows one of two patterns. The right treatment plan for you depends on which is dominant.

You are a Sinker if:

• The hollows under your eyes look deeper than they used to.
• The apples of your cheeks have flattened or lost projection.
• Shadows are appearing where the light used to fall.
• The lid-cheek junction is starting to look longer.

You are a Sagger if:

• Your cheeks have moved south rather than disappeared.
• Soft jowling is forming along the jawline.
• The nasolabial folds are deepening.
• The face still has volume but is sitting in a different area.

Profhilo Structura is exceptional for the early stage of the “Sinker” pattern, and a strong supporting treatment for the “Sagger” pattern when combined with carefully chosen alternatives. We will help you identify your dominant pattern at your Anti-Ageing Consultation.

Profhilo vs Profhilo Structura: a clear comparison

The two treatments are not in competition with each other. They are designed to address different layers of the face.

Many of our patients use both in sequence across the year for a complete bio-remodelling result: Profhilo for skin quality, Structura for structural support.

The treatment experience

A Profhilo Structura session at our St Albans clinic takes approximately 30 minutes. We typically use a fine cannula rather than multiple needle entries, which is more comfortable for the patient, reduces bruising, and allows precise placement within the superficial fat pads.

Depending on your requirements from a “sinker” or “sagger” point of view, there are specific protocols your medical practitioner will follow to carefully address your needs.

The standard protocol is two sessions, four weeks apart, with maintenance every approximately 6 months thereafter, should you desire.

Profhilo Structura downtime: an honest answer

We think honesty matters most here, because expectations shape experience.

• Mild bruising: Possible, particularly around the cheekbones.
• Slight tenderness: Might be noticed when smiling or chewing for a day or two.
• Same-day return to work is typical.

“We always recommend leaving a clear week or longer before any major event, simply for individual variation. There is no significant swelling, no ‘filler face’, and no obvious change for anyone other than you to notice.” Nurse Natalia

Profhilo Structura benefits

Patients who choose Profhilo Structura at The Skin to Love Clinic typically report:

• Restored mid-face support and gentle projection of the cheek apples.
• A softer, more natural-looking lift along the lid-cheek junction.
• May offer reduced shadowing in the under-eye region.
• Improved skin firmness and glow.
• A face that looks like its younger self, not someone else's.

Does Profhilo Structura work?

Yes. Early independent clinical data and our own clinic outcomes are consistent: in the right candidate, Profhilo Structura produces meaningful, measurable improvement in mid-face structure. Studies have demonstrated improvement in skin elasticity, fat pad volume and patient-reported satisfaction following the standard two-session protocol.

Here are a few clinical studies to support Profhilo Structura’s efficacy:

Clinical study 1 Sparavigna A, et al. (2024): Focuses on the "Lipolifting" effect and safety profile.
Clinical study 2 Cassuto D, et al. (2023): The ultrasound study proving the increase in tissue thickness.

Nurse Natalia adds: “It is not a substitute for filler in patients with significant volume loss, and it is not a surgical face lift. It is a precision bio-remodelling treatment for those whose mid-face is just beginning to lose its underlying support, and the earlier the intervention, the more elegantly it performs.”