Profhilo vs Polynucleotides: Which Treatment Is Right for You 

If you’re looking into the world of skin care and injectable treatments, it’s likely that you’ve stumbled upon two buzzworthy treatments: Profhilo and polynucleotides. Both skin treatments are designed to improve your skin quality and rejuvenate, but they work in very different ways-so how do you know which treatment is right for you?

Profhilo is well known for its ability to deeply hydrate the skin tissue as well as its ability to remodel the skin using hyaluronic acid (HA); it results in a natural, refreshed look and smoother skin. On the other hand, polynucleotides treatment, the slightly newer kid on the block, has gained recent attention for its skin regeneration properties. Unlike Profhilo, polynucleotides use molecules derived from DNA to strengthen, repair and regenerate the skin at a cellular level.

With both skin treatments offering beautiful, natural-looking results it’s quite easy to see why the choice between the two can feel overwhelming. This short guide will break down the key differences between a Profhilo injection and polynucleotide injection, to help you make an informed decision.

What is Profhilo?

Having earned its reputation as a go-to skin treatment for skin firming, deep hydration, and an effortless, fresh, glow-it's easy to see why Profhilo is an extremely popular skin treatment... but what makes it different from traditional skin boosters or fillers?

Rather than replacing volume like a dermal filler, Profhilo injections are all about skin quality. Both fillers and Profhilo use hyaluronic acid (HA), but they have a different consistency and role offering very different outcomes. Unlike traditional skin boosters which focus on hydration, Profhilo has a ‘bioremodelling’ action on the skin at a cellular level to improve signs of ageing... in addition to hydrating.

Profhilo injections flood the skin with pure, ultra-concentrated hyaluronic acid (HA) which delivers super intense skin hydration but also, importantly, kick-starts your elastin and collagen production; this improves the skin elasticity, texture, and firmness from within.

You could think of Profhilo as a skin-conditioning treatment that acts beneath the skin surface to restore a bouncy, youthful complexion.

Who Are Profhilo Treatments For?

Profhilo could be the ideal ‘reset’ button if your skin is starting to look dull, crepey, or lack elasticity. Profhilo is also a great option for those of us who simply want to ‘step up’ our skin care regime; in fact, it’s often been called ‘the injectable moisturiser’. It’s a really popular choice for those noticing the first signs of skin ageing as it subtly improves the skin quality and boosts the rejuvenation process without leaving you looking ‘done’.

Profhilo can be used on the mid-to-lower face, neck, decolletage and body areas such as the upper arms. It’s a good option for those wanting an all-over skin refresh and hydration boost.

A full Profhilo treatment consists of two sessions, approximately one month apart, with results lasting around 6 months.

Profhilo offers minimal downtime; usually just a few small bumps at the site of injection that subside within 24 hours. This treatment tends to fit really easily into busy lifestyles as it offers natural, but noticeable skin improvements without the commitment of a lengthy recovery.

What Are Polynucleotides?

They may well be a newer name in medical-aesthetics, but polynucleotides’ skin-repairing benefits are backed by lots of medical research. Polynucleotides were originally used in medicine to help a number of concerns, such as joint restoration, before being used in aesthetics where they’ve been making waves for their ability to heal, restore, and strengthen the skin at a deep, cellular level.

Unlike Profhilo, which primarily firms the skin and deeply hydrates, polynucleotides treatment works by reducing inflammation, repairing DNA, and stimulating fibroblast activity in the skin (the skin cells that are responsible for collagen and elastin regeneration).

Polynucleotides are derived from highly purified DNA fragments, usually from salmon or trout. These DNA fragments have been shown to improve overall skin texture, accelerate the skin's natural repair process, and reduce skin redness. This makes them a fabulous injectable treatment option for compromised skin and/or ageing skin.

Who Are Polynucleotide Treatments For?

Polynucleotides could be your skin care secret weapon if you’re struggling with scars, ageing, or fragile skin. Polynucleotides are especially effective for:

• Restoring skin elasticity in those noticing thinning skin and laxity.

• Strengthening sensitive, reactive skin, such as those with rosacea or previous skin damage.

• Scar healing-including acne scars and post-surgical scars.
• Rejuvenation around the eye-including undereye hollows.
• Increasing overall skin health and your skins collagen production.

Polynucleotides are usually done in a course of three treatments spaced about a month apart. The results develop gradually as your skin’s natural repair and rejuvenate processes work.

There is very little downtime associated with polynucleotides treatment with longer-lasting benefits; improvements are often appreciated for around 9 months. Polynucleotides are well suited for those looking for deep skin repair and rejuvenation rather than instant hydration and rejuvenation.

Polynucleotides vs Profhilo: What’s The Difference?

Both Profhilo and polynucleotides are injectable skin treatments that enhance skin texture and skin health, but as you’ve gathered there are some distinct differences. Let’s compare them side by side:

Both polynucleotides and Profhilo offer natural-looking results, but one may be better suited to your needs and goals than the other. Luckily, both treatments can be incorporated into a skincare plan for you if it’s felt you’ll benefit from both, which leads me on to my next point...

Can You Have Polynucleotides And Profhilo Together?

Yes! Whilst they are certainly different treatments, Profhilo and Polynucleotide treatment can work beautifully together. With our decades of experience, we know that quite often the ultimate results come from a combination of data-backed treatments.

The combination of Profhilo’s deep hydration with hyaluronic acid (HA) and firming action on the skin with polynucleotides ability to strengthen and repair make them a powerful combination and could be part of a comprehensive skin rejuvenation plan.

Your personal skin goals and requirements will determine the best approach for you. A consultation is the first step. You consultation allows you to discuss how you’d like to improve ageing skin and receive guidance from an experienced medical-aesthetic practitioner to determine a treatment plan that’s right for you.

Which of These Skin Treatments is Right for You?

As you’ve probably gathered by now the answer to this depends on your individual needs and your practitioner should give you guidance on this, but generally:

1. If your skin is thinning and in need of repair and rejuvenation-Polynucleotides may be a good option.
2. If your skin is dehydrated and loosing firmness-Profhilo may be for you.
3. If you want the ultimate skin boost-consider combining both treatments.

At our Hertfordshire-based aesthetic clinic, we always take a personalised approach to skin rejuvenation. No matter if you’re interested in having Profhilo injection, a polynucleotide treatment, or perhaps a combination of both, our expert team can create a plan with your specific needs in mind.